However, only a small proportion of women having HPV infection, go on to develop cancer HPV infection has been found to disrupt some tumor suppressor genes, thus allowing cervical cells to grow and multiply uncontrollably.Under normal circumstances, certain genes called tumor suppressor genes, keep a check on the growth and division of cervical cells.Studies indicate that nearly all cases are associated with HPV infection involving high-risk HPV types (such as HPV-18, HPV-16, and HPV-45). The human papilloma virus (HPV) infection is a major cause behind the development of Endocervical Adenocarcinoma, Usual Type. What are the Causes of Endocervical Adenocarcinoma, Usual Type? (Etiology) It is always important to discuss the effect of risk factors with your healthcare provider. Some risk factors are more important than others.Īlso, not having a risk factor does not mean that an individual will not get the condition. A risk factor increases one's chances of getting a condition compared to an individual without the risk factors. It is important to note that having a risk factor does not mean that one will get the condition. Family history of cervical cancer: This is a relatively ‘low strength’ risk factor.Presence of other sexually transmitted infections (such as chlamydia).Having the first child at a young age (before 17 years) and having had multiple pregnancies.Use of oral contraceptives for long time duration this factor is not yet conclusively proven.Lack of periodic/regular Pap smear tests.Poor immune system: HIV infection or AIDS, organ transplantation, immunosuppressant medications, greatly increase risk for chronic infection.Sexual promiscuity (multiple sexual partners) and high-risk sexual behavior.Different subtypes of the virus exist: Types 16, 18, 31, 33, and 45, are the high-risk types associated with cancer of which HPV-18 is the most common type with respect to adenocarcinoma.HPV infection is the most important risk factor predisposing one to cervical cancer.Infection with human papilloma virus (HPV) types:.The following factors increase the risk for Endocervical Adenocarcinoma, Usual Type: What are the Risk Factors for Endocervical Adenocarcinoma, Usual Type? (Predisposing Factors) Hispanic women are commonly affected (in the United States), followed by African-Americans, Asians, and Caucasians. Generally, all racial and ethnic groups are at risk and the cancer is observed worldwide.A small proportion of cancer (about 20% of them) is found in women over 65 years
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